Association between antidepressant use during pregnancy and autism spectrum disorder in children: a retrospective cohort study based on Japanese claims data

Table 3 Odds ratios for ASD diagnosis in the children of mothers using/not using antidepressants during pregnancy

Antidepressant exposure	All children	Children with ASD	Age at ASD diagnosis^a)	Crude OR		Model 1 OR^b)		Model 2 OR^c)
Antidepressant exposure	n	n (%)	average (SD), month	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Non-user	26,730	423 (1.58)	39.1 (14.8)	1 (Reference)	–	1 (Reference)	–	1 (Reference)	–
User	195	7 (3.59)	41.3 (18.5)	2.32 (1.08, 4.95)	0.03	2.37 (1.10, 5.09)	0.03	0.76 (0.27, 2.18)	0.61

Abbreviations: OR, odds ratio; CI, confidence interval
^a)Age at which the child was first diagnosed with ASD.
^b)Adjusted for maternal age at birth and gender of the child.
^c)Adjusted for maternal age at birth, gender of the child, and maternal depression diagnosis during pregnancy (Disorders F31, F32, or F33; International Classification of Disorders).

ISSN: 2054-958X