Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study

Kassem, Zeinab; Sitarik, Alexandra; Levin, Albert M.; Lynch, Susan V.; Havstad, Suzanne; Fujimura, Kei; Kozyrskyj, Anita; Ownby, Dennis R.; Johnson, Christine Cole; Yong, Germaine J. M.; Wegienka, Ganesa; Cassidy-Bushrow, Andrea E.

doi:10.1186/s40748-020-00119-x

Maternal Health, Neonatology and Perinatology

Table 3 Alpha diversity metrics by deseasonalized maternal Vitamin D, overall and by race

From: Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study

Outcome	Model	β^a	SE	p-value
1-Month
Prenatal Vitamin D
Richness	Overall (unadjusted)	−4.872	1.201	<.001
	Overall (adjusted for race)^b	−3.293	1.488	0.028
	Black	−4.409	1.912	0.022
	White	−1.548	2.371	0.515
	Interaction p-value			0.35
Evenness	Overall (unadjusted)	−0.004	0.002	0.046
	Overall (adjusted for race)^b	− 0.002	0.003	0.498
	Black	−0.004	0.003	0.26
	White	0.001	0.004	0.76
	Interaction p-value			0.347
Diversity	Overall (unadjusted)	−0.293	0.063	<.001
	Overall (adjusted for race)^b	−0.199	0.079	0.012
	Black	−0.281	0.101	0.006
	White	−0.071	0.125	0.567
	Interaction p-value			0.195
Cord Vitamin D
Richness	Overall (unadjusted)	−6.363	2.306	0.006
	Overall (adjusted for race)^b	−2.001	2.660	0.453
	Black	−5.955	3.455	0.087
	White	3.516	4.126	0.397
	Interaction p-value			0.079
Evenness	Overall (unadjusted)	−0.005	0.004	0.219
	Overall (adjusted for race)^b	0.002	0.005	0.712
	Black	−0.009	0.007	0.194
	White	0.017	0.008	0.044
	Interaction p-value			0.016
Diversity	Overall (unadjusted)	−0.385	0.122	0.002
	Overall (adjusted for race)^b	−0.174	0.142	0.223
	Black	−0.370	0.191	0.055
	White	0.100	0.206	0.629
	Interaction p-value			0.103
6-Months
Prenatal Vitamin D
Richness	Overall (unadjusted)	−4.447	1.513	0.004
	Overall (adjusted for race)^b	−2.324	1.852	0.211
	Black	−2.364	2.590	0.363
	White	−2.276	2.626	0.388
	Interaction p-value			0.981
Evenness	Overall (unadjusted)	−0.004	0.002	0.097
	Overall (adjusted for race)^b	−0.001	0.003	0.643
	Black	0.000	0.004	0.973
	White	−0.003	0.005	0.553
	Interaction p-value			0.648
Diversity	Overall (unadjusted)	−0.229	0.075	0.003
	Overall (adjusted for race)^b	−0.116	0.091	0.206
	Black	−0.167	0.128	0.195
	White	−0.055	0.128	0.667
	Interaction p-value			0.544
Cord Vitamin D
Richness	Overall (unadjusted)	−8.437	2.860	0.004
	Overall (adjusted for race)^b	−6.181	3.300	0.063
	Black	−10.201	4.241	0.018
	White	0.673	5.153	0.897
	Interaction p-value			0.112
Evenness	Overall (unadjusted)	−0.007	0.005	0.166
	Overall (adjusted for race)^b	−0.008	0.006	0.177
	Black	−0.017	0.007	0.025
	White	0.007	0.010	0.475
	Interaction p-value			0.053
Diversity	Overall (unadjusted)	−0.409	0.140	0.004
	Overall (adjusted for race)^b	−0.300	0.159	0.061
	Black	−0.479	0.205	0.021
	White	0.006	0.248	0.979
	Interaction p-value			0.141

SE standard error
^aEstimated change in alpha diversity measure for a 5 ng/mL increase in vitamin D
^bRestricted to Black or White only, so reduced sample size compared to unadjusted

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ISSN: 2054-958X

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