From: Antibiotic exposure and growth patterns in preterm, very low birth weight infants
Weight Delta Z-score at Age of Evaluation | |||||
---|---|---|---|---|---|
~ 36 weeks | ~ 2 months | ~ 4 months | ~ 6 months | ~ 12 months | |
No. of infants | 161 | 151 | 134 | 136 | 129 |
Gestational age | 0.274b | 0.477b | 0.446b | 0.445b | 0.479b |
Mode of delivery | 0.270b,c | 0.177b,c | 0.121 | 0.130 | 0.111 |
Multiple gestation | 0.091 | 0.081 | 0.034 | 0.022 | 0.025 |
Sex | −0.208d,e | − 0.111 | − 0.072 | − 0.091 | − 0.040 |
IUGR | 0.052 | 0.194b | 0.163 | 0.164 | 0.162 |
SGA | 0.059 | 0.078 | 0.191b | 0.247b | 0.250b |
CRIB-II score | −0.206d | −0.379d | − 0.334d | − 0.310d | −0.321d |
Antibiotic exposure (days of therapy [DOT]) | −0.375b | −0.295b | − 0.151 | −0.080 | − 0.119 |
BPD | −0.294d | − 0.262d | −0.195d | − 0.127 | −0.209d |
PDA | −0.138 | −0.107 | − 0.077 | −0.053 | − 0.112 |
NEC | −0.174 | − 0.023 | 0.051 | 0.069 | 0.035 |
Late-onset sepsis | −0.074 | −0.192d | − 0.129 | −0.052 | − 0.075 |
TPN (total days) | −0.397d | − 0.356d | −0.206d | − 0.131 | −0.127 |
Total days of NPO | −0.367d | −1.313d | −0.177 | − 0.092 | −0.109 |
Caloric density (36 weeks, kcal/ounce) | −0.024 | 0.066 | 0.022 | 0.018 | 0.006 |