Fig. 8

Management of pulmonary hypertension in CDH: pulmonary vasodilators and nitric oxide – prostacyclin – endothelin pathways. AC – acetylcholine, Ca- calcium, cAMP - cyclic adenosine monophosphate, cGMP – cyclic guanosine monophosphate, COX – cycloxygenase, eNOS – endothelial nitric oxide synthase, ET – endothelin, EP – prostaglandin E receptor, IP – prostacyclin I receptor, NO – nitric oxide, PGI – prostaglandin I, sGC - soluble guanylyl cyclase, PDE – phosphodiesterase inhibitor (Copyright Satyan Lakshminrusimha)