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Table 2 Vasoactive medications commonly used in CDH: Typical doses, route of administration of inotropic and vasodilator medications in the management of CDH

From: Congenital Diaphragmatic hernia – a review

Drug

Route

Units

Initial dose

Maintenance Dose range

DOPAmine

IV

μg/kg/min

1 to 5

1 to 50 (usually 2.5 to 20)

DOBUTamine

IV

μg/kg/min

1 to 5

1 to 40 (usually 2.5 to 20)

EPInephrine

IV

μg/kg/min

0.05 to 0.1

0.1 to 1

NOREPInephrine

IV

μg/kg/min

0.05 to 0.1

0.05 to 2

PGE1 – Alprostadil

IV

μg/kg/min

0.05 to 0.1

0.01 to 4

PGE1 – Alprostadil

Inhaled

μg/kg/min

0.15 to 0.3

0.15 to 0.3

Milrinone

IV

μg/kg/min

0.25 to 0.75 (some units use a load of 50 μg/kg)

0.25 to 1

Dexamethasone

IV

mg/kg/dose

0.05 to 0.6

0.05 to 0.6

Hydrocortisone

IV

mg/kg/dose

1 to 5

0.5 to 5

Nitric oxide (NO)

Inhaled

Ppm

5 to 20

1 to 80

Vasopressin

IV

Units/kg/min

0.0001 to 0.002

0.0001 to 0.008

Prostacyclin (Epoprostenol - Flolan)

IV

ng/kg/min

1 to 3

50 to 80

Prostacyclin (Epoprostenol - Flolan)

Inhaled

ng/kg/min

50

25 to 50

Prostacyclin (Treprostinil – Remodulin)

SQ or IV

ng/kg/min

1.25 to 2

50 to 80

Prostacyclin (Treprostinil – Remodulin)

Inhaled

μg/breath

6

 

Prostacyclin (Iloprost)

Inhaled

μg/breath

2.5 or 5

 

Prostacyclin (Beraprost)

PO

μg

80

80 to 120 (adult dose)

Sildenafil

IV

mg/kg/h

0.14 for 3 h

0.07

Bosentan

PO

mg/kg/dose

1 to 2

1 to 2