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Table 2 Vasoactive medications commonly used in CDH: Typical doses, route of administration of inotropic and vasodilator medications in the management of CDH

From: Congenital Diaphragmatic hernia – a review

Drug Route Units Initial dose Maintenance Dose range
DOPAmine IV μg/kg/min 1 to 5 1 to 50 (usually 2.5 to 20)
DOBUTamine IV μg/kg/min 1 to 5 1 to 40 (usually 2.5 to 20)
EPInephrine IV μg/kg/min 0.05 to 0.1 0.1 to 1
NOREPInephrine IV μg/kg/min 0.05 to 0.1 0.05 to 2
PGE1 – Alprostadil IV μg/kg/min 0.05 to 0.1 0.01 to 4
PGE1 – Alprostadil Inhaled μg/kg/min 0.15 to 0.3 0.15 to 0.3
Milrinone IV μg/kg/min 0.25 to 0.75 (some units use a load of 50 μg/kg) 0.25 to 1
Dexamethasone IV mg/kg/dose 0.05 to 0.6 0.05 to 0.6
Hydrocortisone IV mg/kg/dose 1 to 5 0.5 to 5
Nitric oxide (NO) Inhaled Ppm 5 to 20 1 to 80
Vasopressin IV Units/kg/min 0.0001 to 0.002 0.0001 to 0.008
Prostacyclin (Epoprostenol - Flolan) IV ng/kg/min 1 to 3 50 to 80
Prostacyclin (Epoprostenol - Flolan) Inhaled ng/kg/min 50 25 to 50
Prostacyclin (Treprostinil – Remodulin) SQ or IV ng/kg/min 1.25 to 2 50 to 80
Prostacyclin (Treprostinil – Remodulin) Inhaled μg/breath 6  
Prostacyclin (Iloprost) Inhaled μg/breath 2.5 or 5  
Prostacyclin (Beraprost) PO μg 80 80 to 120 (adult dose)
Sildenafil IV mg/kg/h 0.14 for 3 h 0.07
Bosentan PO mg/kg/dose 1 to 2 1 to 2