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Table 1 Methodologies for continuous glucose monitoring

From: Continuous glucose monitoring in neonates: a review

Fluid location Biosensor Advantages Disadvantages Commercial devices currently used in neonates
Subcutaneous Microdialysis fibre with external amperometric probe. Most accurate. Subcutaneous inflammation. Not available
Sensing element is outside the skin and so is not susceptible to biofouling.
Expensive.
Long lag time.
Discomfort.
Requires calibration.
Amperometric needle electrode. Easier insertion. Less accurate. Medtronic MiniMed.
Sensor degradation due to biofouling.
DexCom.
Poor detection with oedema.  
Discomfort.
Most require calibration.
 
Transdermal Glucose binding protein. No skin penetration. Accuracy unknown. Not yet available.
Potentially suitable in neonates due to their high trans-epidermal water loss.
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