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Table 1 Pharmacokinetic data on milrinone in various age groups - modified from Lakshminrusimha et al. [43]

From: Milrinone in congenital diaphragmatic hernia – a randomized pilot trial: study protocol, review of literature and survey of current practices

Age group

Loading dose

Maintenance dose

Half-life (h)

Total body clearance (mL/kg/min)

Volume of distribution (L/kg)

Adult [44]

12.5 to 75 μg/kg

0.5 μg/kg/min

0.8 ± 0.22

6.1 ± 1.3

0.32 ± 0.08

Child [45]

25 to 75 μg/kg

0.25 to 0.75 μg/kg/min

3.7

2.5 to 10.6 (increases with age)

0.7–0.9

Neonate (post-op CHD) [21]

25 μg /kg over 60 min (low dose)

75 μg /kg (high dose)

0.25 μg /kg/ min (low dose)

0.75 μg /kg/min (high dose)

 

1.64 ± 0.37

0.523 ± 0.028

Neonate (PPHN) [46] [47]

50 μg /kg over 60 min

0.33 (to 0.99) μg /kg/min

4.1 ± 1.1

1.83 ± 0.17 to 3.05

0.56 ± 0.19

Preterm neonate [32]

0.75 μg /kg/min for 3 h

0.2 μg /kg/min

10.3

0.64

0.576