Age group | Loading dose | Maintenance dose | Half-life (h) | Total body clearance (mL/kg/min) | Volume of distribution (L/kg) |
---|---|---|---|---|---|
Adult [44] | 12.5 to 75 μg/kg | 0.5 μg/kg/min | 0.8 ± 0.22 | 6.1 ± 1.3 | 0.32 ± 0.08 |
Child [45] | 25 to 75 μg/kg | 0.25 to 0.75 μg/kg/min | 3.7 | 2.5 to 10.6 (increases with age) | 0.7–0.9 |
Neonate (post-op CHD) [21] | 25 μg /kg over 60 min (low dose) 75 μg /kg (high dose) | 0.25 μg /kg/ min (low dose) 0.75 μg /kg/min (high dose) | 1.64 ± 0.37 | 0.523 ± 0.028 | |
50 μg /kg over 60 min | 0.33 (to 0.99) μg /kg/min | 4.1 ± 1.1 | 1.83 ± 0.17 to 3.05 | 0.56 ± 0.19 | |
Preterm neonate [32] | 0.75 μg /kg/min for 3 h | 0.2 μg /kg/min | 10.3 | 0.64 | 0.576 |