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Table 1 Pharmacokinetic data on milrinone in various age groups - modified from Lakshminrusimha et al. [43]

From: Milrinone in congenital diaphragmatic hernia – a randomized pilot trial: study protocol, review of literature and survey of current practices

Age group Loading dose Maintenance dose Half-life (h) Total body clearance (mL/kg/min) Volume of distribution (L/kg)
Adult [44] 12.5 to 75 μg/kg 0.5 μg/kg/min 0.8 ± 0.22 6.1 ± 1.3 0.32 ± 0.08
Child [45] 25 to 75 μg/kg 0.25 to 0.75 μg/kg/min 3.7 2.5 to 10.6 (increases with age) 0.7–0.9
Neonate (post-op CHD) [21] 25 μg /kg over 60 min (low dose) 75 μg /kg (high dose) 0.25 μg /kg/ min (low dose) 0.75 μg /kg/min (high dose)   1.64 ± 0.37 0.523 ± 0.028
Neonate (PPHN) [46] [47] 50 μg /kg over 60 min 0.33 (to 0.99) μg /kg/min 4.1 ± 1.1 1.83 ± 0.17 to 3.05 0.56 ± 0.19
Preterm neonate [32] 0.75 μg /kg/min for 3 h 0.2 μg /kg/min 10.3 0.64 0.576