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Table 4 Associations between maternal infection and timing of maternal infection during pregnancy and inflammatory markers

From: Maternal infections during pregnancy and offspring midlife inflammation

   CRP IL-6 IL-10 TNF-α
  Cases Crude Factor (95% CI) Factor (95% CI)* Crude Factor (95% CI) Factor (95% CI)* Crude Factor (95% CI) Factor (95% CI)* Crude Factor (95% CI) Factor (95% CI)*
Infection during pregnancy 392 0.93 (0.81,1.06) 0.93 (0.81,1.06) 0.92 (0.84,1.01) 0.92 (0.85,1.01) 0.91;(0.77,1.08) 0.91 (0.77,1.08) 0.99 (0.94,1.03) 0.99 (0.94,1.04)
Timing of infection          
Never 1313 1 1 1 1 1 1 1 1
Trimester 1 55 1.04 (0.78,1.34) 1.05 (0.80,1.38) 0.88 (0.73,1.06) 0.90 (0.74,1.07) 0.95 (0.85,1.06) 0.95 (0.66,1.36) 0.95 (0.85,1.06) 0.95 (0.85,1.06)
Trimester 2 &/or 3 Trimester 1 & later in pregnancy 317 20 0.90 (0.78,1.02) 0.90 (0.78,1.02) 0.90 (0.79,1.03) 0.90 (0.78,1.02) 0.92 (0.84,1.02) 0.90 (0.78,1.02) 0.93 (0.84,1.02) 0.90 (0.78,1.02) 0.99 (0.94,1.04) 0.90 (0.78,1.02) 0.91 (0.76,1.09) 0.90 (0.78,1.02) 0.99 (0.94,1.04) 0.90 (0.78,1.02) 0.99 (0.94,1.04) 0.90 (0.78,1.02)
  1. The factors and 95% confidence intervals (CI) are presented. Analyses based on 1719 men and women with continuous participation in the Copenhagen Perinatal Cohort and the Copenhagen Aging and Midlife Bioank
  2. *Controlled for parity, maternal age, maternal pre-pregnancy BMI and smoking in the last trimester, maternal civil status, gender
  3. BMI body mass index, CRP C-reactive protein, IL-6 Interleukin-6, IL-10 Interleukin-10, TNF-α tumor necrosis factor-α