Skip to main content

Table 2 Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Intention to treat analysis

From: Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

  Cord Clamping Group, Mean (SD) Difference (95% CI) P valuea
Intact cord > 3 min Early < 1 min)
Readings from pulse oximeter (n = 129) (n = 93)   
 Saturation at 1 min (%) 71.5 (9.3) 62.4 (4.3) 9.1 (7.3 to 11.0) <.001
 Saturation at 5 min (%) 83.6 (8.3) 76.6 (4.1) 7.0 (5.3 to 8.7) <.001
 Saturation at 10 min (%) 90.4 (8.1) 85.4 (2.7) 5.0 (3.5 to 6.5) <.001
 Heart rate at 1 min 105 (3) 116 (5) −10 (− 11 to −9) <.001
 Heart rate at 5 min 124 (4) 134 (4) −10 (− 11 to − 8) <.001
 Heart rate at 10 min 136 (2) 135 (2) 1 (0 to 1) .03
Apgar score (n = 134) (n = 97)   
 Apgar at 1 min 5.1 (1.0) 4.3 (1.0) 0.8 (0.5 to 1.1) <.001
 Apgar at 5 min 6.8 (0.7) 6.5 (1.1) 0.3 (0.1 to 0.5) .01
 Apgar at 10 min 9.4 (1.0) 9.0 (1.5) 0.4 (0.2 to 0.7) .03
Timed events, Median (interquartile range) (n = 134) (n = 97)   
 Time of start of resuscitation (sec) 45 (28 to 68) 45 (25 to 59)   . 19b
 Time of first cry/breath (sec) 37 (34 to 44) 45 (38 to 50)   <.001b
 Time of regular breathing (sec)c 78 (67 to 96) 98 (89 to 356)   <.001b
 Time to cord clamping (sec) 104 (30 to 191) 25 (14 to 40)   <.001b
Measurements after resuscitation
 Baby’s temperature (C°)d 36.2 (0.5) 36.2 (0.5) 0.0 (−0.1 to 0.1) .82
 Transcutaneous bilirubin (μmol/L) at dischargee 97.8 (52.5) 89.1 (52.6) 8.6 (−5.5 to 23.0) .23
  1. aCalculated using an unpaired 2-tailed t test
  2. bCalculated using Mann Whitney U test
  3. cIntact cord group n = 132 and the early group n = 93
  4. dIntact cord group n = 127 and the early group n = 90
  5. eAge (hours) at discharge was median (interquartile range) 21.6 (15.4 to 31.6) in the intact cord group (n = 128) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .83