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Table 2 Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Intention to treat analysis

From: Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

 

Cord Clamping Group, Mean (SD)

Difference (95% CI)

P valuea

Intact cord > 3 min

Early < 1 min)

Readings from pulse oximeter

(n = 129)

(n = 93)

  

 Saturation at 1 min (%)

71.5 (9.3)

62.4 (4.3)

9.1 (7.3 to 11.0)

<.001

 Saturation at 5 min (%)

83.6 (8.3)

76.6 (4.1)

7.0 (5.3 to 8.7)

<.001

 Saturation at 10 min (%)

90.4 (8.1)

85.4 (2.7)

5.0 (3.5 to 6.5)

<.001

 Heart rate at 1 min

105 (3)

116 (5)

−10 (− 11 to −9)

<.001

 Heart rate at 5 min

124 (4)

134 (4)

−10 (− 11 to − 8)

<.001

 Heart rate at 10 min

136 (2)

135 (2)

1 (0 to 1)

.03

Apgar score

(n = 134)

(n = 97)

  

 Apgar at 1 min

5.1 (1.0)

4.3 (1.0)

0.8 (0.5 to 1.1)

<.001

 Apgar at 5 min

6.8 (0.7)

6.5 (1.1)

0.3 (0.1 to 0.5)

.01

 Apgar at 10 min

9.4 (1.0)

9.0 (1.5)

0.4 (0.2 to 0.7)

.03

Timed events, Median (interquartile range)

(n = 134)

(n = 97)

  

 Time of start of resuscitation (sec)

45 (28 to 68)

45 (25 to 59)

 

. 19b

 Time of first cry/breath (sec)

37 (34 to 44)

45 (38 to 50)

 

<.001b

 Time of regular breathing (sec)c

78 (67 to 96)

98 (89 to 356)

 

<.001b

 Time to cord clamping (sec)

104 (30 to 191)

25 (14 to 40)

 

<.001b

Measurements after resuscitation

 Baby’s temperature (C°)d

36.2 (0.5)

36.2 (0.5)

0.0 (−0.1 to 0.1)

.82

 Transcutaneous bilirubin (μmol/L) at dischargee

97.8 (52.5)

89.1 (52.6)

8.6 (−5.5 to 23.0)

.23

  1. aCalculated using an unpaired 2-tailed t test
  2. bCalculated using Mann Whitney U test
  3. cIntact cord group n = 132 and the early group n = 93
  4. dIntact cord group n = 127 and the early group n = 90
  5. eAge (hours) at discharge was median (interquartile range) 21.6 (15.4 to 31.6) in the intact cord group (n = 128) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .83