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Table 3 Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Only infants handled according to allocation (per protocol) analyzed

From: Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

  Cord Clamping Group, Mean (SD) Difference (95% CI) P valuea
Intact cord > 3 min Early < 1 min
Readings from pulse oximeter (n = 63) (n = 93)   
 Saturation at 1 min (%) 79.8 (3.6) 62.4 (4.3) 17.4 (16.1 to 18.7) <.001
 Saturation at 5 min (%) 91.4 (3.1) 76.6 (4.1) 14.8 (13.6 to 16.0) <.001
 Saturation at 10 min (%) 98.0 (1.4) 85.4 (2.7) 12.6 (11.8 to 13.3) <.001
 Heart rate at 1 min 105 (3) 116 (5) −11 (−12 to −10) <.001
 Heart rate at 5 min 125 (3) 134 (4) −9 (−10 to −7) <.001
 Heart rate at 10 min 137 (2) 135 (2) 2 (1 to 2) <.001
Apgar score (n = 63) (n = 93)   
 Apgar at 1 min 5.7 (0.9) 4.3 (0.9) 1.4 (1.1 to 1.6) <.001
 Apgar at 5 min 7.0 (0.5) 6.6 (0.9) 0.5 (0.2 to 0.7) <.001
 Apgar at 10 min 9.6 (0.7) 9.0 (1.3) 0.6 (0.2 to 1.0) .001
Timed events, Median (interquartile range) (n = 65) (n = 97)   
 Time of start of resuscitation (sec) 40 (22 to 60) 45 (25 to 59)   .62b
 Time of first cry/breath (sec) 34 (28 to 39) 45 (38 to 50)   <.001b
 Time of regular breathing (sec)c 69 (34 to 399) 98 (89 to 356)   <.001b
 Time to cord clamping (sec) 192 (188 to 200) 25 (14 to 40)   <.001b
Measurements after resuscitation
 Baby’s temperature (C°) 30 min after birthd 36.2 (0.6) 36.2 (0.5) 0.0 (−0.2 to 0.2) .82
 Transcutaneous bilirubin (μmol/L) at dischargee 94.4 (44.1) 89.1 (52.6) 5.3 (−11.0 to 21.7) .52
  1. aCalculated using an unpaired 2-tailed t test
  2. bCalculated using Mann Whitney U test
  3. cIntact cord group n = 65 and the early group n = 93
  4. dIntact cord group n = 64 and the early group n = 90
  5. eAge (hours) at discharge was median (interquartile range) 22.5 (16.2 to 32.1) in the intact cord group (n = 61) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .81
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