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Table 3 Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control). Only infants handled according to allocation (per protocol) analyzed

From: Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

 

Cord Clamping Group, Mean (SD)

Difference (95% CI)

P valuea

Intact cord > 3 min

Early < 1 min

Readings from pulse oximeter

(n = 63)

(n = 93)

  

 Saturation at 1 min (%)

79.8 (3.6)

62.4 (4.3)

17.4 (16.1 to 18.7)

<.001

 Saturation at 5 min (%)

91.4 (3.1)

76.6 (4.1)

14.8 (13.6 to 16.0)

<.001

 Saturation at 10 min (%)

98.0 (1.4)

85.4 (2.7)

12.6 (11.8 to 13.3)

<.001

 Heart rate at 1 min

105 (3)

116 (5)

−11 (−12 to −10)

<.001

 Heart rate at 5 min

125 (3)

134 (4)

−9 (−10 to −7)

<.001

 Heart rate at 10 min

137 (2)

135 (2)

2 (1 to 2)

<.001

Apgar score

(n = 63)

(n = 93)

  

 Apgar at 1 min

5.7 (0.9)

4.3 (0.9)

1.4 (1.1 to 1.6)

<.001

 Apgar at 5 min

7.0 (0.5)

6.6 (0.9)

0.5 (0.2 to 0.7)

<.001

 Apgar at 10 min

9.6 (0.7)

9.0 (1.3)

0.6 (0.2 to 1.0)

.001

Timed events, Median (interquartile range)

(n = 65)

(n = 97)

  

 Time of start of resuscitation (sec)

40 (22 to 60)

45 (25 to 59)

 

.62b

 Time of first cry/breath (sec)

34 (28 to 39)

45 (38 to 50)

 

<.001b

 Time of regular breathing (sec)c

69 (34 to 399)

98 (89 to 356)

 

<.001b

 Time to cord clamping (sec)

192 (188 to 200)

25 (14 to 40)

 

<.001b

Measurements after resuscitation

 Baby’s temperature (C°) 30 min after birthd

36.2 (0.6)

36.2 (0.5)

0.0 (−0.2 to 0.2)

.82

 Transcutaneous bilirubin (μmol/L) at dischargee

94.4 (44.1)

89.1 (52.6)

5.3 (−11.0 to 21.7)

.52

  1. aCalculated using an unpaired 2-tailed t test
  2. bCalculated using Mann Whitney U test
  3. cIntact cord group n = 65 and the early group n = 93
  4. dIntact cord group n = 64 and the early group n = 90
  5. eAge (hours) at discharge was median (interquartile range) 22.5 (16.2 to 32.1) in the intact cord group (n = 61) vs 22.2 (14.5 to 33.9) in the early group (n = 95), p = .81