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Table 4 Measurements from infants who were randomized to resuscitation with an intact cord (intervention) or after early cord clamping (control), only including those resuscitated with bag and mask

From: Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial

 

Cord Clamping Group, Mean (SD)

Difference (95% CI)

P-valuea

Intact cord > 3 min

Early < 1 min)

Readings from pulse oximeter

(n = 72)

(n = 45)

  

 Saturation at 1 min (%)

73.7 (8.8)

62.6 (5.0)

11.1 (8.2 to 13.9)

<.001

 Saturation at 5 min (%)

85.6 (8.1)

76.1 (3.9)

9.4 (6.9 to 12.0)

<.001

 Saturation at 10 min (%)

91.9 (7.9)

85.1 (2.8)

6.8 (4.4 to 9.3)

<.001

 Heart rate at 1 min

106 (3)

115 (5)

−10 (−11 to −8)

<.001

 Heart rate at 5 min

124 (4)

134 (4)

−10 (− 11 to −8)

<.001

 Heart rate at 10 min

136 (2)

136 (2)

1 (0 to 2)

.05

Apgar score

(n = 74)

(n = 48)

  

 Apgar at 1 min

5.0 (1.1)

3.8 (1.1)

1.2 (0.8 to 1.6)

< 0.001

 Apgar at 5 min

6.7 (0.9)

6.0 (1.3)

0.7 (0.3 to 1.1)

0.001

 Apgar at 10 min

9.2 (1.2)

8.3 (1.8)

0.9 (0.3 to 1.5)

0.005

Timed events, Median (interquartile range)

(n = 74)

(n = 48)

  

 Time of start of resuscitation (sec)

48 (30 to 71)

43 (23 to 57)

 

. 06b

 Time of first cry/breath (sec)

38 (34 to 45)

48 (45 to 62)

 

<.001b

 Time of regular breathing (sec)c

78 (67 to 155)

356 (98 to 389)

 

<.001b

 Time to cord clamping (sec)

187 (42 to 195)

25 (11 to 40)

 

<.001 b

  1. aCalculated using an unpaired 2-tailed t test
  2. bCalculated using Mann Whitney U test
  3. cIntact cord group n = 72 and the early group n = 45