Antibiotic exposure and growth patterns in preterm, very low birth weight infants

Table 2 Weight delta z-scores from birth to subsequent age points by univariate linear regression analysis^a

	Weight Delta Z-score at Age of Evaluation
	~ 36 weeks	~ 2 months	~ 4 months	~ 6 months	~ 12 months
No. of infants	161	151	134	136	129
Gestational age	0.274^b	0.477^b	0.446^b	0.445^b	0.479^b
Mode of delivery	0.270^b,c	0.177^b,c	0.121	0.130	0.111
Multiple gestation	0.091	0.081	0.034	0.022	0.025
Sex	−0.208^d,e	− 0.111	− 0.072	− 0.091	− 0.040
IUGR	0.052	0.194^b	0.163	0.164	0.162
SGA	0.059	0.078	0.191^b	0.247^b	0.250^b
CRIB-II score	−0.206^d	−0.379^d	− 0.334^d	− 0.310^d	−0.321^d
Antibiotic exposure (days of therapy [DOT])	−0.375^b	−0.295^b	− 0.151	−0.080	− 0.119
BPD	−0.294^d	− 0.262^d	−0.195^d	− 0.127	−0.209^d
PDA	−0.138	−0.107	− 0.077	−0.053	− 0.112
NEC	−0.174	− 0.023	0.051	0.069	0.035
Late-onset sepsis	−0.074	−0.192^d	− 0.129	−0.052	− 0.075
TPN (total days)	−0.397^d	− 0.356^d	−0.206^d	− 0.131	−0.127
Total days of NPO	−0.367^d	−1.313^d	−0.177	− 0.092	−0.109
Caloric density (36 weeks, kcal/ounce)	−0.024	0.066	0.022	0.018	0.006

IUGR intrauterine growth restriction, SGA small for gestational age, CRIB Clinical Risk Index for Babies, BPD bronchopulmonary dysplasia, PDA patent ductus arteriosus, NEC necrotizing enterocolitis, TPN total parenteral nutrition, NPO nothing per oral
^aPearson correlation
^bPositive correlation, P < 0.05
^cPositive correlation with delivery by caesarean section
^dNegative correlation, P < 0.05
^eNegative correlation with male sex

ISSN: 2054-958X