Table 1 Descriptive summary of the studies included in the review
From: Outcomes of neonatal hypothermia among very low birth weight infants: a Meta-analysis
Study | Study Year | Country | Adverse outcomes found to be associated with HT | HT cut point (°C) | No. of VLBW infants | No. (%) of infants with HT |
|---|---|---|---|---|---|---|
Levi et al. [38] | 1981 | USA | Mortality | 36.0 | 71 | 53 (74.6%) |
Neonatal Data Collection Group [33] | 1993 | Malaysia | Mortality | 36.0 | 824 | 280 (33.9%) |
Malaysian VLBW group [34] | 1997 | Malaysia | Mortality | 36.0 | 868 | 288 (33.2%) |
Laptook et al. [13] | 2003 | USA | Mortality (28% increase per 1 °C decrease) and sepsis (11% increase per 1 °C decrease) | 36.0 | 5277 | 2475 (46.9%) |
Sodemann et al. [39] | 2003 | Guinea-Bissau | Mortality | 34.5 | 23 | 13 (56.5%) |
Demirel et al. [35] | 2006 | Turkey | BPD | 36.0 | 106 | 32 (30.1%) |
Miller et al. [6] | 2007 | USA | Mortality, IVH, and sepsis | 36.5 | 8782 | 4953 (56.4%) |
Ogunlesi et al. [32] | 2008 | Nigeria | Mortality | 36.5 | 15 | 14 (93.3%) |
Ting et al. [7] | 2011 | Canada | Mortality, sepsis and adverse neurodevelopmental outcomes | 36.5 | 2739 | 968 (35.3%) |
Audeh et al. [24] | 2011 | Israel | Non | 35.5 | 271 | 100 (36.9%) |
Lyu et al. [37] | 2012 | Canada | Mortality, severe neurological injury, severe ROP, NEC, and BPD | 36.5 | 9833 | 3516 (35.7%) |
De Almeida et al. [20] | 2012 | Brazil | Mortality | 36.0 | 1764 | 900 (51.0%) |
Guinsburg et al. [12] | 2015 | Brazil | Unfavorable outcome (in-hospital mortality or survival with BPD, IVH III/IV, PVL and/or ROP) | 36.0 | 2646 | 868 (32.8%) |
Chang et al. [10] | 2015 | Taiwan | Mortality and RDS | 36.5 | 341 | 262 (76.8%) |
Das et al. [36] | 2016 | USA | Sepsis | 36.0 | 174 | 16 (9.19%) |
Caldas et al. [9] | 2019 | Brazil | Mortality and NEC | 36.5 | 4356 | 2339 (53.7%) |
Ng’eny et al. [11] | 2019 | South Africa | Mortality and metabolic acidosis | 36.0 | 799 | 453 (56.7%) |
Yu et al. [5] | 2020 | China | Mortality, RDS, IVH, NEC, and sepsis | 36.5 | 1247 | 1100 (88.2%) |