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Intact cord resuscitation versus early cord clamping in the treatment of depressed newborn infants during the first 10 minutes of birth (Nepcord III) – a randomized clinical trial


A randomized clinical trial of resuscitation with early cord clamping or resuscitation with an intact umbilical cord in late-preterm and term infants born by vaginal delivery and not breathing at 30 nepcord s after birth. Nurse-midwives trained in Helping Babies Breathe (HBB – © American Academy of Pediatrics) conducted the trial. The benefits of an intact umbilical cord for at least 180 s (identified by *) included higher preductal pulse oximetry (SpO2) and Apgar scores at 1, 5 and 10 min after birth and lower heart rate at 1 and 5 min. Delayed cord clamping also resulted in earlier cry/breathing. Body temperature after resuscitation and transcutaneous bilirubin at discharge were similar between early and delayed cord clamping groups.

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Aims and scope

Maternal Health, Neonatology and Perinatology is an open access, peer-reviewed journal that considers articles on a broad range of topics related to the physiological and pathological conditions of women during preconceptional, perinatal, and postpartum periods; and of fetuses and newborn infants during and beyond their initial hospital stay. The topics within these subjects could include, but are not limited to, the etiology, epidemiology, clinical issues, diagnosis, prevention, treatment, and short and long-term outcomes. Read more here.

Maternal Health, Neonatology and Perinatology is affiliated with the CROWN initiative, Core Outcomes in Women’s Health. CROWN is an international initiative, led by journal editors, to harmonise outcome reporting in women’s health research. We are coming together to address the widespread, unwarranted variation in reporting of outcomes. CROWN’s main aim is to encourage researchers to report core outcome sets for key conditions in women’s health.

Dr. Irina Burd is Associate Professor of Gynecology and Obstetrics and Neurology at the Johns Hopkins University.  She was recruited to the Johns Hopkins University to spearhead the development of the field of Fetal Medicine and Fetal Neurology, and is the founder and Director of the Johns Hopkins Integrated Research Center for Fetal Medicine, and Director of Maternal Fetal Medicine Fellowship. 

Prior to coming to Johns Hopkins University, Dr. Burd earned Bachelor of Arts Degree from Rutgers University (Summa Cum Laude) and completed the combined Rutgers University/Princeton University MD/PhD Program.  She completed her residency in Obstetrics and Gynecology at the Thomas Jefferson University and her fellowship in Maternal Fetal Medicine at the University of Pennsylvania. Dr. Burd developed research program studying the pathogenesis of fetal brain injury with exposure to intrauterine inflammation, and studies prenatally used neuroprotective agents to prevent cerebral palsy and a spectrum of neurobehavioral outcomes. She is studying how assessment of placental anatomy and function can be utilized for evaluation of fetal brain injury in utero, and guidance for administration of neuroprotective and immunomodulatory therapies. For her work and her unique area of expertise, Dr. Burd was selected as a Chair of NICHD Obstetrics and Maternal Fetal Medicine Subcommittee.

Dr. Jonathan Slaughter is a neonatologist and principal investigator in the Center for Perinatal Research within The Research Institute at Nationwide Children's Hospital and an Assistant Professor of Pediatrics and Epidemiology at The Ohio State University. His scholarly pursuits include neonatal comparative effectiveness research and neonatal pharmacoepidemiology. When teaching in the neonatal intensive care unit, he emphasizes the critical evaluation of published literature and evidence-based practice.

Prior to coming to Nationwide Children’s/Ohio State, Dr. Slaughter earned a Bachelor of Arts Degree from Catawba College (Summa Cum Laude) and a Doctor of Medicine degree from the Wake Forest University School of Medicine. He completed his residency in Pediatrics at the Medical University of South Carolina and his fellowship in Neonatal-Perinatal Medicine at Cincinnati Children’s Hospital Medical Center. He received his Master of Public Health degree from The Ohio State University College of Public Health. Dr. Slaughter was elected as a member of the Society for Pediatric Research and has served as the Chair of the International Society for Pharmacoepidemiology Pediatric Special Interest Group. He is a voting member on the Ohio Newborn Screening Advisory Council.

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73 days to first decision for reviewed manuscripts only
55 days to first decision for all manuscripts
116 days from submission to acceptance
58 days from acceptance to publication

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