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Table 1 List of manuscripts reporting the use of umbilical cord blood for neonatal testing, along with brief description of findings

From: New and underutilized uses of umbilical cord blood in neonatal care

Laboratory Test Author, year Comments
CBC Hansen, 2005 [5] 113 term infant paired umbilical cord & neonatal samples. High correlation of WBC, hematocrit, platelets. I:T ratio reported.
  Carroll, 2011 [3] 174 preterm infant umbilical cord & neonatal paired samples. High correlation of WBC, hemoglobin, platelets. False positive thrombocytopenia on 4 cord samples.
  Christensen, 2011 [4] 10 VLBW infant pilot study. No difference in CBC compared to historical controls.
  Beeram, 2012 [2] 200 term and preterm infant umbilical cord & neonatal paired samples. Similar results between sources. Higher rate of leukopenia in cord samples noted.
  Baer, 2013 [10] 91 VLBW infants. No paired samples. Outcome study.
  Rotshenker-Olshinka, 2014 [6] 305 term and preterm infant umbilical cord & neonatal paired samples. Significant correlation between cord and infant CBC.
Blood Culture Polin, 1981 [8] 200 cord blood cultures with 29 paired infant cultures. Cord sterilized with 2 % tincture of iodine. One septic patient had positive cord and infant culture. Similar contamination rate between cord samples (2.5 %) and infant samples (3.4 %)
  Herson, 1998 [7] 81 term infants, 35 high risk umbilical cord & neonatal paired samples. Placental vein sterilized with povidone-iodine. 5 mL blood samples from cord obtained. 20 % true positive from cord vs. 3 % true positive from infant cultures of paired samples.
  Hansen, 2005 [5] 113 term infants. Cord sterilized with alcohol. Zero contaminants or true positive cultures
  Christensen, 2011 [4] 10 VLBW infant pilot study. No positive cultures from cases or historical controls.
  Beeram, 2012 [2] 200 term and preterm umbilical cord & neonatal paired samples. Cord sterilized with povidone-iodine and then swabbed with alcohol. 2 contaminants from cord blood. One contaminant and one pathogen from infant blood.
  Baer, 2013 [10] 91 VLBW infants. Prospective outcome study with historical controls.
  Rotshenker-Olshinka, 2014 [6] 223 term and preterm infant umbilical cord & neonatal paired samples. Cord sterilized with chlorhexidine prior to placental delivery. No cases of sepsis. High contamination rate from both cord sample (12.5 %) and infant sample (2.5 %).
Blood Type AAP, 2004 [13] Recommends “direct antibody test, blood type, and Rh (D) type on the infant’s (cord) blood.”
  Judd, 2001 [12] Practice guideline for immunohematology. Endorses obtaining blood type from cord blood or infant blood.
  Christensen, 2011 [4] 10 VLBW infant pilot prospective outcome study with historical controls.
  Baer, 2013 [10] 91 VLBW infants. Prospective outcome study with historical controls.
Antibody Screen Josephson, 2011 [13] American Association of Blood Banking technical manual. Recommends antibody testing using plasma or serum from the infant or mother.
  Christensen, 2011 [4] 10 VLBW infant pilot study.
  Baer, 2013 [10] 91 VLBW infants. No paired samples. Outcome study.
Newborn Metabolic Screen Miller, 2008 [14] CLSI Newborn screening guidelines. Recommends first newborn metabolic test be obtained upon admission of premature infants.
  Christensen, 2011 [4] 10 VLBW infant pilot study.
  Baer, 2013 [10] 91 VLBW infants. No paired samples. Outcome study.