Table 1 List of manuscripts reporting the use of umbilical cord blood for neonatal testing, along with brief description of findings
From: New and underutilized uses of umbilical cord blood in neonatal care
Laboratory Test | Author, year | Comments |
|---|---|---|
CBC | Hansen, 2005 [5] | 113 term infant paired umbilical cord & neonatal samples. High correlation of WBC, hematocrit, platelets. I:T ratio reported. |
Carroll, 2011 [3] | 174 preterm infant umbilical cord & neonatal paired samples. High correlation of WBC, hemoglobin, platelets. False positive thrombocytopenia on 4 cord samples. | |
Christensen, 2011 [4] | 10 VLBW infant pilot study. No difference in CBC compared to historical controls. | |
Beeram, 2012 [2] | 200 term and preterm infant umbilical cord & neonatal paired samples. Similar results between sources. Higher rate of leukopenia in cord samples noted. | |
Baer, 2013 [10] | 91 VLBW infants. No paired samples. Outcome study. | |
Rotshenker-Olshinka, 2014 [6] | 305 term and preterm infant umbilical cord & neonatal paired samples. Significant correlation between cord and infant CBC. | |
Blood Culture | Polin, 1981 [8] | 200 cord blood cultures with 29 paired infant cultures. Cord sterilized with 2 % tincture of iodine. One septic patient had positive cord and infant culture. Similar contamination rate between cord samples (2.5 %) and infant samples (3.4 %) |
Herson, 1998 [7] | 81 term infants, 35 high risk umbilical cord & neonatal paired samples. Placental vein sterilized with povidone-iodine. 5 mL blood samples from cord obtained. 20 % true positive from cord vs. 3 % true positive from infant cultures of paired samples. | |
Hansen, 2005 [5] | 113 term infants. Cord sterilized with alcohol. Zero contaminants or true positive cultures | |
Christensen, 2011 [4] | 10 VLBW infant pilot study. No positive cultures from cases or historical controls. | |
Beeram, 2012 [2] | 200 term and preterm umbilical cord & neonatal paired samples. Cord sterilized with povidone-iodine and then swabbed with alcohol. 2 contaminants from cord blood. One contaminant and one pathogen from infant blood. | |
Baer, 2013 [10] | 91 VLBW infants. Prospective outcome study with historical controls. | |
Rotshenker-Olshinka, 2014 [6] | 223 term and preterm infant umbilical cord & neonatal paired samples. Cord sterilized with chlorhexidine prior to placental delivery. No cases of sepsis. High contamination rate from both cord sample (12.5 %) and infant sample (2.5 %). | |
Blood Type | AAP, 2004 [13] | Recommends “direct antibody test, blood type, and Rh (D) type on the infant’s (cord) blood.” |
Judd, 2001 [12] | Practice guideline for immunohematology. Endorses obtaining blood type from cord blood or infant blood. | |
Christensen, 2011 [4] | 10 VLBW infant pilot prospective outcome study with historical controls. | |
Baer, 2013 [10] | 91 VLBW infants. Prospective outcome study with historical controls. | |
Antibody Screen | Josephson, 2011 [13] | American Association of Blood Banking technical manual. Recommends antibody testing using plasma or serum from the infant or mother. |
Christensen, 2011 [4] | 10 VLBW infant pilot study. | |
Baer, 2013 [10] | 91 VLBW infants. No paired samples. Outcome study. | |
Newborn Metabolic Screen | Miller, 2008 [14] | CLSI Newborn screening guidelines. Recommends first newborn metabolic test be obtained upon admission of premature infants. |
Christensen, 2011 [4] | 10 VLBW infant pilot study. | |
Baer, 2013 [10] | 91 VLBW infants. No paired samples. Outcome study. |