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Table 3 Treatment adherence and follow-up of enrolled infants

From: Simplified antibiotic regimens for treating neonates and young infants with severe infections in the Democratic Republic of Congo: a comparative efficacy trial

Regimena A B C D
Number of infants enrolled 148 139 148 139
Treatment adherence
 Received all treatment doses as per-protocol 146 (98.6%) 137 (98.6%) 144 (97.3%) 135 (97.1%)
 Did not receive all doses, but met per-protocol analysis criteria 2 (1.4%) 1 (0.7%) 4 (2.7%) 4 (2.9%)
 Did not meet per-protocol analysis criteria for treatment 0 1b (0.7%) 0 0
Follow up by independent outcome assessor
 Received all independent outcome assessment visits 145 (98.0%) 133 (95.7%) 145 (98.0%) 133 (95.7%)
 Did not receive all independent outcome assessment visits, but met per-protocol analysis criteria 2 (1.4%) 3 (2.2%) 2 (1.4%) 4 (2.9%)
 Did not meet per-protocol analysis criteria for assessment 2 (1.3%) 4 (3.0%) 4 (2.7%) 4 (3.0%)
Included in per-protocol analysis (met both treatment and assessment criteria) 146 (98.6%) 135 (97.1%) 144 (97.3%) 135 (97.1%)
  1. aRegimen A: IM Gentamicin and IM Penicillin × 7 days; Regimen B: IM Gentamicin and oral amoxicillin × 7 days; Regimen C: IM Gentamicin × 7 days and IM Penicillin × 2 days then oral amoxicillin × 5 days; Regimen D: IM Gentamicin × 2 days and oral amoxicillin × 7 days
  2. bInfant failed to meet both per-protocol treatment adherence and outcome assessment criteria