Simplified antibiotic regimens for treating neonates and young infants with severe infections in the Democratic Republic of Congo: a comparative efficacy trial

Table 3 Treatment adherence and follow-up of enrolled infants

Regimen^a	A	B	C	D
Number of infants enrolled	148	139	148	139
Treatment adherence
Received all treatment doses as per-protocol	146 (98.6%)	137 (98.6%)	144 (97.3%)	135 (97.1%)
Did not receive all doses, but met per-protocol analysis criteria	2 (1.4%)	1 (0.7%)	4 (2.7%)	4 (2.9%)
Did not meet per-protocol analysis criteria for treatment	0	1^b (0.7%)	0	0
Follow up by independent outcome assessor
Received all independent outcome assessment visits	145 (98.0%)	133 (95.7%)	145 (98.0%)	133 (95.7%)
Did not receive all independent outcome assessment visits, but met per-protocol analysis criteria	2 (1.4%)	3 (2.2%)	2 (1.4%)	4 (2.9%)
Did not meet per-protocol analysis criteria for assessment	2 (1.3%)	4 (3.0%)	4 (2.7%)	4 (3.0%)
Included in per-protocol analysis (met both treatment and assessment criteria)	146 (98.6%)	135 (97.1%)	144 (97.3%)	135 (97.1%)

^aRegimen A: IM Gentamicin and IM Penicillin × 7 days; Regimen B: IM Gentamicin and oral amoxicillin × 7 days; Regimen C: IM Gentamicin × 7 days and IM Penicillin × 2 days then oral amoxicillin × 5 days; Regimen D: IM Gentamicin × 2 days and oral amoxicillin × 7 days
^bInfant failed to meet both per-protocol treatment adherence and outcome assessment criteria