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Table 3 Crude linear regression coefficients showing the association between increases in continuous covariates on inflammatory markers

From: Maternal infections during pregnancy and offspring midlife inflammation

 

Continuous variables/Geometric mean

 

CRP

IL-6

IL-10

TNF-α

Maternal pre-pregnancy BMI (kg/m2)

1.02 (1.00,1.03)

1.01 (1.00,1.02)

1.00 (1.00,1.01)

1.00 (0.97,1.02)

Maternal age at birth (years)

0.99 (0.98,0.99)

1.00 (0.99,1.00)

1.00 (1.00,1.00)

1.00 (0.99,1.01)

Parity

    

 1

1.20

1.65

4.48

1.15

 2

1.12

1.60

4.39

1.22

 3

1.21

1.70

4.31

1.35

 4

0.91

1.68

4.35

1.17

 5+

1.63

2.14

5.16

1.02

p-value for difference

0.06

0.01

0.09

0.56

Infection during pregnancy

    

 No

1.20

1.68

4.44

1.22

 Yes

1.09

1.54

4.39

1.12

p-value for difference

0.18

0.06

0.53

0.28

Maternal civil status at conception

    

 Married mother

1.03

1.60

4.39

1.19

 Unmarried mother

1.35

1.78

4.53

1.19

p-value for difference

< 0.001

0.001

0.22

0.90

Tobacco smoking in pregnancy

    

 No

1.13

1.63

4.39

1.22

 Yes

1.21

1.68

4.48

1.15

p-value for difference*

0.25

0.45

0.27

0.42

Child’s gender

    

 Male

1.15

1.67

4.66

1.22

 Female

1.20

1.65

4.22

1.17

p-value for difference*

0.48

0.93

< 0.001

0.64

  1. Geometric means by categories of categorical covariates with corresponding p-values
  2. BMI body mass index, CRP C-reactive protein, IL-6 Interleukin-6, IL-10 Interleukin-10, TNF-α tumor necrosis factor-α, *p-values obtained using ANOVA