Antibiotic exposure and growth patterns in preterm, very low birth weight infants

Table 3 Length delta z-score from birth to subsequent age points by univariate linear regression analysis^a

	Length Delta Z-score at Age of Evaluation
	~ 36 weeks	~ 2 months	~ 4 months	~ 6 months	~ 12 months
No. of infants	161	151	134	136	129
Gestational age	0.042	0.281^b	0.329^b	0.222^b	0.251^b
Delivery mode	0.159^b,c	0.191^b,c	0.118	0.052	0.073
Multiple gestation	0.015	0.076	0.061	0.042	0.086
Sex	−0.069	−0.116	− 0.014	− 0.018	− 0.016
IUGR	0.253^d	0.091	0.041	0.070	0.043
SGA	0.106	0.039	0.219^b	0.283^b	0.291^b
CRIB-II score	0.263	0.244^d	0.232^d	0.130	0.118
Antibiotic exposure (days of therapy [DOT])	0.021	−0.144	−0.092	−0.040	−0.077
BPD	−0.120	−0.216^d	− 0.217^d	−0.138	− 0.130
PDA	−0.153	− 0.171^d	−0.151	0.008	0.018
NEC	−0.020	0.015	−0.002	0.073	0.003
Late-onset sepsis	0.244^b	−0.019	−0.056	− 0.049	0.007
TPN (total days)	0.033	−0.216^d	−0.159	− 0.073	−0.112
Caloric density (36 weeks, kcal/ounce)	−0.070	0.003	0.012	0.015	0.081

IUGR intrauterine growth restriction, SGA small for gestational age, CRIB Clinical Risk Index for Babies, BPD bronchopulmonary dysplasia, PDA patent ductus arteriosus, NEC necrotizing enterocolitis, TPN total parenteral nutrition
^aPearson correlation
^bPositive correlation, P < 0.05
^cPositive correlation with delivery by caesarean section
^dNegative correlation, P < 0.05

ISSN: 2054-958X